Genomewide Expression Profiling of Cryptolepine-Induced Toxicity in Saccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae.
We have used the budding yeast Saccharomyces cerevisiae to identify genes that may confer sensitivity in vivo to the antimalarial and cytotoxic agent cryptolepine. Five S. cerevisiae strains, with different genetic backgrounds in cell permeability and DNA damage repair mechanisms, were exposed to several concentrations of cryptolepine. Cryptolepine showed a relatively mild toxicity for wild-typ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00532-08